In response to the COVID-19 outbreak, Nussenzweig has extended this research to SARS-CoV-2 and is working to isolate and characterize highly potent neutralizing antibodies from patients who have recovered from the disease. Phase III+: The University is open for expanded research operations; only authorized personnel will be admitted on campus. During inflammation or infection, dendritic cells present self-antigens simultaneously with non-self-antigens. Verified email at rockefeller.edu. Nature 561, 479–484 (2018). Escolano, A. et al. Nature 570, 468–473 (2019). This paradigm has been extended to other viruses such as hepatitis B and flaviviruses. HHMI, The Rockefeller University. ... michel nussenzweig. Immunology. Current studies focus on outlining the pathway of human dendritic cell development and differentiation. All rights reserved. New findings characterize human antibody response to SARS-Cov-2, with implications for convalescent plasma therapy, vaccine design, and antibody-based drugs. Hypermutation and selection occur in specialized micro-anatomical compartments called germinal centers. Nussenzweig received tenure at NIH in 2003. In clinical trials conducted at The Rockefeller University Hospital, two of these antibodies interfered with chronic HIV infection, driving the amount of virus in the blood to below detectable levels. Protein amounts of the MYC transcription factor determine germinal center B cell division capacity. Most people infected with the coronavirus are able to fight it off because their immune system produces effective antibodies. In 2011, Dr. Nussenzweig established a new department at NCI called the Laboratory of Genome Integrity. Nussenzweig’s experiments are consistent with the notion that self-antigens taken up by dendritic cells induce tolerance, whereas antigens taken up in the context of activation stimuli, such as those found during inflammation or tissue destruction, induce prolonged T cell activation. This work has helped establish a new paradigm for developing vaccines and therapies for infectious diseases. Nussenzweig’s laboratory investigates the molecular basis of such hypermutation, and the selection for high affinity antibody-producing cells in the germinal center. Most of these receptors have relatively low affinity for their antigens and must be refined by somatic hypermutation and class switch recombination, yielding high-affinity antibodies that protect against most pathogens, including HIV-1. The answer may be a nuanced “no.”, COVID-19 immunology study reveals universally effective antibodies, Scientists are using ‘elite’ antibodies from COVID-19 survivors to develop potent therapies. And unlike traditional antiretroviral therapy, which requires daily dosing, the antibodies continue to provide protection and treatment for months after they have been administered, suggesting they might lead to long-term control of the virus. M.D., 1982New York University School of Medicine, Internship and Residency in medicine, 1982–1985Fellowship in infectious diseases, 1984–1985Massachusetts General Hospital, Assistant Professor, 1990–1994Associate Professor, 1994–1996Professor, 1996–Director, Christopher Browne Center for Immunology and Immune Diseases, 2011–The Rockefeller University, Senior Physician, 1996–The Rockefeller University Hospital, Assistant Investigator, 1990–1995Associate Investigator, 1995–1999Investigator, 1999–Howard Hughes Medical Institute, Meritorious Career Award, American Association of Immunologists–Huang Foundation, 2004, Lee C. Howley Sr. Prize for Arthritis Research, 2008, Rabbi Shai Shacknai Memorial Prize in Immunology and Cancer Research, 2016, National Academy of SciencesNational Academy of MedicineAmerican Academy of Arts and SciencesBrazilian Academy of Sciences. Title. Rockefeller scientists are working to turn such antibodies into a drug. Michel C. Nussenzweig (born February 10, 1955) is a professor and head of the Laboratory of Molecular Immunology at The Rockefeller University and a Howard Hughes Medical Institute investigator. Nussenzweig’s laboratory studies the molecular aspects of the immune system’s innate and adaptive responses using a combination of biochemistry, molecular biology, and genetics. He is a member of both the US National Academy of Medicine and the US National Academy of Sciences More info here. Sort by citations Sort by year Sort by title. Clinical Research and the Rockefeller University Hospital, Chemers Neustein Summer Undergraduate Research Fellowship Program, Experience Science, the Arts, and Culture. Kirby Center for Sensory Neuroscience, Pels Family Center for Biochemistry and Structural Biology, Shelby White and Leon Levy Center for Mind, Brain and Behavior, Center for Clinical and Translational Science. Combination therapy with anti-HIV-1 antibodies maintains viral suppression. How they work and collaborate might never again be the same. Michel Nussenzweig is interested in the molecular aspects of the immune system’s innate and adaptive responses. Gabriel D Victora Laurie and Peter Grauer Assistant Professor and Head, Laboratory of Lymphocyte Dynamics, The Verified email at rockefeller.edu. The microanatomic segregation of selection by apoptosis in the germinal center. Cell 169, 597–609 (2017). Phase III+: The University is open for expanded research operations; only authorized personnel will be admitted on campus. Articles Cited by Co-authors. Nussenzweig’s research aims to understand the rules that govern hypermutation and high affinity antibody selection, with the goal of creating vaccines for pathogens such as HIV-1. His work is leading to new antibody-based therapies for infections by HIV and the novel SARS-CoV-2 coronavirus, among other viruses. Meet the scientific leaders who are changing medicine, Peek inside our 70 biomedical laboratories, Learn more about our flexible, supportive academic programs, Learn about the breakthroughs happening every day, Hear from the world’s leading speakers and thinkers, We’ve spent 119 years perfecting the bioscience institute, Will SARS-CoV-2 escape future drugs by mutating? Recently, the lab defined distinct progenitor lineages for classical spleen dendritic cells, plasmacytoid dendritic cells, and monocytes, a step toward antigen-specific targeting. Copyright 2004—2020 The Rockefeller University. Studies the molecular aspects of adaptive and innate immune responses with a focus on HIV-1.
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